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  • Cancer vaccine just tested specifically melanoma

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    Yes—the personalized mRNA #melanoma vaccine i just heard about has just reported positive Phase 3 results. It’s called intismeran autogene (also known as #mRNA‑4157 or V940) and is being developed by #Moderna and Merck.

    It’s made for an individual patient using the genetic fingerprint of their melanoma.

    In the trial, it was given after surgery, alongside #Keytruda, to people with higher-risk melanoma.
    Among 1,137 participants, the combination lowered the relative risk of the melanoma returning or death by 42% compared with Keytruda alone. At two years, about 82% of people on the combination were alive without recurrence, compared with 70% on Keytruda alone.

    A couple of important details:• The trial met its main goals, but researchers are still following patients to assess longer-term outcomes, including overall survival. • It’s for certain patients with melanoma removed by surgery—it’s not a preventive shot for everyone or a treatment for ordinary basal-cell or squamous-cell skin cancers. • It’s not yet an approved, generally available treatment; the companies say they’re discussing regulatory submissions. • The $12,000 figure is probably for Keytruda, not the experimental vaccine. Merck lists Keytruda at $12,517.44 per dose every three weeks (or $25,034.88 for its six-week dose); that’s the list price, and most insured patients don’t pay that full amount. The vaccine’s price hasn’t been announced.

  • Objective analysis. I personally use magnesium glyconate and magnesium L theanate they have helped improve my mental acuity, memory, and actually they’re very calming. I don’t take any other drugs except B6. This just shows you how much marketing hype there is and everything.

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    These are supplements marketed for men’s performance. The big numbers on the bottles are totals for ingredient mixtures; they do not mean 1,800 mg of testosterone or 2,250 mg of pure nitric oxide.

    Testosterone Complex: The label lists D-aspartic acid, zinc, magnesium, B6, and several herbs, including tribulus, maca, long jack, horny goat weed, and mucuna. It’s sold as a way to support testosterone, but research on “testosterone booster” blends has not shown reliable evidence that they meaningfully raise testosterone.

    Nitric Oxide Booster: This is a blend of arginine and citrulline, amino acids involved in the body’s nitric-oxide pathway. Nitric oxide helps blood vessels relax, which is why products like this are promoted for circulation, workout “pump,” or sexual performance. But the evidence that arginine supplements improve exercise performance or blood flow is limited and mixed.

    The main caution: Arginine may lower blood pressure. It can interact with blood-pressure medicines, nitrate heart medicines, and sildenafil (Viagra), potentially lowering blood pressure too much.  The testosterone blend also contains several herbs, so I’d have a pharmacist review it alongside any medicines or other supplements before trying it.

    If someone is concerned about low testosterone, the reliable next step is a clinician’s evaluation and blood tests: guidelines call for symptoms plus consistently low results, confirmed with repeat morning testing.

  • They see lot of new drugs, peptides, anti-aging drugs. I used to teach chemistry. I know a little bit. I’m just interested in Harvard studies where they’re actually programming neurons by light, switching things on and off, and actual anti-aging strategies where be we stop the cells from aging. This is all speculation, just something for you to read

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    KPV is a tiny peptide made of three amino acids: lysine, proline and valine. Researchers study it for possible anti-inflammatory effects. It’s related to the end of a natural hormone called α‑MSH, but KPV itself isn’t a weight-loss drug—and Lilly isn’t developing it as one.

    The key distinction is that the promising claims are mostly based on lab and animal research. The FDA says it found no human clinical studies of KPV and that its safety in people is unknown. So when you hear it discussed alongside weight-loss drugs, that’s a list of different “peptides,” not evidence that they all work the same way or have the same level of testing.

  • Weight loss and peptides

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    Share a few recent shots from your camera roll, no context needed.

    You’re probably thinking of retatrutide (“reh-tuh-TROO-tide”), Eli Lilly’s experimental weight-loss medicine. It’s a peptide drug—a chain of amino acids designed to act on hormone receptors in the body. It’s given as a once-weekly injection in clinical trials.

    What makes it different is that it activates three hormone receptors: GLP‑1, GIP and glucagon. In simple terms, these signals affect appetite, digestion and blood-sugar regulation; the glucagon action may also affect how the body uses energy. This makes it a “triple agonist.” Tirzepatide, the drug in Zepbound and Mounjaro, acts on two of those receptors.

    In a large Phase 3 obesity trial, participants without diabetes lost an average of about 25% of their body weight after 80 weeks at the highest studied dose. That’s a strong result, but it comes from a clinical trial; it doesn’t tell us how well the drug will work for every person or what its long-term effects will be. The most common reported side effects were gastrointestinal, such as nausea and diarrhea.

    As of today, retatrutide is still investigational and is not FDA-approved. It is not legally available as a prescription medicine. Products advertised online as “research” or “peptide” retatrutide are not the same as Lilly’s trial medicine, and their contents and quality may be uncertain.

    So, the short version: it’s a promising Lilly drug in late-stage testing—not an approved supplement or something to buy online.

  • Cooking oil, be sure and read the label

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    , I’d pick extra-virgin olive oil for everyday cooking and salads, and canola oil when you want a neutral-tasting oil. Both are liquid plant oils that the American Heart Association lists as heart-healthy choices.

    https://hsph.harvard.edu/news/are-seed-oils-healthful-or-harmful/
    This is a full article from an academic source. It’s very, very important. Most of the oils we
    Yours are not good at all. It’s not just your heart, it’s your circulatory system, your bowel movements, everything. Be really, really careful. She’s onto something, but there’s not enough detail

  • Herbs & absorption

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    Mostly true, but overstated. Curcumin by itself has very poor bioavailability because it is poorly absorbed and is rapidly metabolized in the intestine and liver; a small human study found that adding 20 mg piperine to 2 g curcumin increased measured bioavailability by about 2,000%.

    The correction is that this does not mean every curcumin product becomes 20× more effective clinically—the 2,000% figure refers to blood exposure under specific study conditions. And piperine can also alter the metabolism of some medications, so “more absorption” is not automatically better.

    In a concise manner, the fundamental mechanism is accurate; the 2,000% figure is accurate but context-dependent, and “barely survives your liver” is an oversimplification.

  • Red Light is a long wavelength and an astrophysicist believes it’s a human nutrient

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    https://youtu.be/5VRypR6NsoU

  • 10 foods from Aldi’s that are quality. This is a family run German store no fancy bakery no fancy people no bags just quality food check for specials. I just got some goat milk there. I love that stuff.

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    https://youtu.be/yef_NNHU7bc

  • Fake butter dont buy non- salted

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    Stay away from Cedar oil canola oil is from Canada, but it’s also called rape seed oil. It used to be a lubricant.

    https://youtu.be/dQClzkJJ5xk

  • Eye

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    Meibomian gland dysfunction (MGD) is basically an oil-gland problem in the eyelids.

    The meibomian glands sit along the edges of your upper and lower lids. They normally release a thin oil called meibum into your tears. That oil keeps the watery part of the tears from evaporating too quickly.

    With MGD, those glands become blocked, inflamed, or produce oil that is too thick. The result is usually evaporative dry eye: burning, gritty or sandy feeling, fluctuating vision, watery eyes, redness, crusting around the lids, or eyes that get tired easily.

    A useful way to picture it:

    Tear film = water + mucus + oil.
MGD = not enough good oil → tears evaporate too fast → dry, irritated eye.

    Common treatment starts with warm compresses and gentle eyelid massage/cleaning to soften and release the oil. Persistent cases may be treated by an eye doctor with gland expression, prescription drops, or procedures such as thermal pulsation or intense pulsed light depending on the cause.

    It’s extremely common and tends to become more common with age. It’s usually manageable, but chronic blockage can eventually cause some of the glands to shrink or disappear.

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